Table 2.
Cohort Specific Assessments at Month 0 and Month 12
| Cohort | Patient population | Assessments |
|---|---|---|
| EPAD (UK) | Cognitively unimpaired to MCI |
Clinical and cognitive data • Spontaneous speech assessment* • Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)* • TabCat tasks: - Favourites Recall - Delay Recall - Recognition - Dot Counting - Flanker • 4 Mountains Test • Virtual Reality Supermarket Trolley Self-reported Questionnaires • Geriatric Depression Scale (GDS) • State-Trait Anxiety Inventory (STAI) • Healthy Ageing Through Internet Counselling in the Elderly (HATICE) • Swedish National study on Aging and Care (SNAC) • The Pittsburgh Sleep Quality Index • Lifestyle questionnaire • Covid-19 questionnaire • Research Experience Questionnaire • Personality using Big Five Inventory-10 (BFI-10) • Brain Injury Screening Questionnaire (BISQ) • International Physical Activity Questionnaire (IPAQ) • Social Networking Questionnaire (SNQ) • Amsterdam Instrumental Activities of Daily Living Questionnaire (AIADLs) Biomaterial • SST Gold (Serum) • EDTA Lavender (DNA) • EDTA Lavender (Blood Count) • EDTA Lavender (Plasma/Buffy Coat) |
| DESCRIBE (Germany) DELCODE (Germany) | Cognitively unimpaired to MCI |
Clinical and cognitive data • Mini-Mental State Examination (MMSE) • Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) • Neuropsychological Testing (NPT) factor scores • Geriatric Depression Scale (GDS) • Geriatric Anxiety Inventory (GAI) • Neuropsychiatric Inventory Questionnaire (NPI-Q) • Alzheimer’s Disease Assessment Scale (ADAS) • Measurement of Everyday Cognition (ECog) • NPT long-term consolidation Biomaterial • CSF Biomarker (Abeta 40 & 42 and p-Tau) • ApoE e4 Genotyp MRI / PET • Structural MRI • PET scans (Amyloid +/ - status) |
| BioFINDER Primary Care (Sweden) | Cognitively unimpaired to MCI |
Clinical and cognitive data • The Montreal Cognitive Assessment (MOCA) • Mini-Mental State Examination (MMSE) • The 10-word list from ADAS-cog (immediate, delayed and recognition recall) • Symbol Digit Modalities Test (SDMT) • Animal Fluency • Cube copying • The clock drawing test • Immediate and delayed recall of pictures test • Trail Making Test A and B • Mini-Cog • CANTAB Paired Associate Learning (iPad) • CANTAB Reaction Time (iPad) • Mezurio Gallery game (smartphone) • Mezurio Tilt Task (smartphone) • Digital Clock Test • Cognitive symptom questionnaire • Amsterdam iADL scale Biomaterial • CSF • Plasma MRI / PET • 18F-flutemetamol PET (small subset where CSF is not available) |
| Beta-AARC (Spain) | Cognitively unimpaired to MCI |
Clinical and cognitive data • Subjective cognitive decline • Cognitive reserve Questionaire • Family history • Life style habits • Brief COPE-28 • NEO-FFI • Attitudes regarding aging - ERA 12 • Mini-Mental State Examination (MMSE) • Memory Alteration Test (M@T) • Free and Cued Selective Reminding Test (FCSRT) • WMS-IV-Logical Memory • WAIS-IV Visual Puzzles, Matrix reasoning and Coding • Trail Making Test (TMT) • 5 digit test • Semantic Fluency • Altoida digital biomarker Biomaterial • CSF Amyloid Status and p-tau measures • Blood Based Biomarkers • APOE e4 status MRI / PET • 3T MRI |
These are assessments that are cohort specific, and are done at month 0 and month 12 in addition to what is stated in Table 1; * Audio was recorded during these tasks.