TABLE 3.
Ig-specific anti-MSP4 antibodies in Vietnam residents susceptible to and potentially protected against P. falciparum infection based on the presence or absence of P. falciparum parasitemia during the surveillance perioda
Isotype | Antibody prevalence (%)
|
Median antibody level (OD)
|
||||
---|---|---|---|---|---|---|
Susceptible (n = 47) | Protected (n = 33) | P (χ2) | Susceptible (n = 47) | Protected (n = 33) | P (U) | |
IgG1 | 87.2 | 66.7 | 0.027 | 0.132 (0.071, 0.555) | 0.204 (0.031, 0.674) | 0.584 |
IgG2 | 27.7 | 36.4 | 0.408 | 0.010 (0.005, 0.031) | 0.010 (0.004, 0.053) | 0.914 |
IgG3 | 76.6 | 72.7 | 0.694 | 0.360 (0.060, 1.082) | 0.241 (0.048, 0.726) | 0.476 |
IgG4 | 0 | 3.0 | 0.230 | 0.002 (−0.001, 0.005) | 0.002 (0.000, 0.003) | 0.445 |
IgM | 23.4 | 21.2 | 0.817 | 0.164 (0.109, 0.283) | 0.132 (0.089, 0.232) | 0.485 |
See Table 2, footnotes a, b, and c. The threshold for significance is 0.0102 after an adjustment is made for the number of comparisons.