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. 2023 Jan 18;15(1):2162306. doi: 10.1080/19490976.2022.2162306

Figure 4.

Figure 4.

(a) F. saccharivorans was significantly lower in individuals with comorbid symptoms of PTSD + depression + state and trait anxiety (mdn = 1.12) (after correcting for main covariates) compared to individuals without these comorbid symptoms (mdn = 2.78) (GLM, p = 0.0001, r = 0.24, n = 198) and (b) compared to healthy controls (mdn = 2.82) (correction for confounding variables not possible) (Wilcoxon rank-sum tests, q = 0.1, n = 114). (c) Proteobacteria was higher in individuals with depressive symptoms (mdn = 3.42) (GLM, p = 0.02, n = 198) compared to those without (mdn = 3.02) whilst (d) Synergistetes were lower in those with depressive symptoms (mdn = −2.98) (GLM, p = 0.004, n = 198) compared to those without (mdn = −2.80). Sample sizes: PTSD + depression, state- and trait-anxiety symptoms Yes n = 8, PTSD + depression, state- and trait-anxiety symptoms No n = 190. Depressive symptoms Yes n = 32, Depressive symptoms No n = 166, Healthy controls n = 106. Solid lines indicate the median; the tops and bottoms of boxes indicate the third and first quartiles, respectively. Whiskers indicate the 1.5 IQR beyond the upper and lower quartiles. Dots represent individual data points. Abbreviations: clr – centered log-ratio, r = effect size. Significance * for p ≤ 0.05, ** for p ≤ 0.005, *** for p ≤ 0.0001, # for q ≤ 0.1. Fusicatenibacter saccharivorans – F. saccharivorans, posttraumatic stress disorder – PTSD, generalized linear model – GLM.