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. 2022 Apr 18;19(2):379–387. doi: 10.1080/15548627.2022.2062112

Figure 1.

Figure 1.

Acetylation of autophagy initiation machinery. Acetylation of ULK1 by the acetyltranferase KAT5/TIP60 activates the ULK1 complex, and acetylation of PIK3C3 and BECN1 regulated by the acetyltransferase EP300 and the deacetylase SIRT1 inhibits the BECN1-PIK3C3 complex, both of which control the initiation of autophagy. Ac, acetylation; ATG, autophagy-related; BECN1, beclin 1; EP300/p300, E1A binding protein p300; KAT5/TIP60, lysine acetyltransferase 5; RB1CC1/FIP200, RB1 inducible coiled-coil 1; SIRT1, sirtuin 1; ULK1, unc-51 like autophagy activating kinase 1; PIK3C3/VPS34, phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3R4, phosphoinositide-3-kinase regulatory subunit 4.