Table 1.

Acetyltransferases and deacetylases that modify autophagy-related proteins*.

Acetyltransferases	Target proteins	Acetylation sites	Deacetylases	Effects on autophagy	Underlying mechanisms	References
EP300	BECN1	K430, K437	SIRT1	Inhibits autophagy initiation	Decreases PIK3C3 activity	[23]
	PIK3C3	K29, K771, K781	Unknown	Inhibits autophagy initiation	Decreases PIK3C3 activity	[7]
EP300-CREBBP	LC3	K49, K51	SIRT1	Inhibits LC3 lipidation	Inhibits the redistribution of nuclear LC3 into cytoplasm and the binding of LC3 to ATG7	[3,4,32]
	ATG5	Unknown	SIRT1	Unknown	Unknown	[3,32]
	ATG7	Unknown	SIRT1	Unknown	Unknown	[3,32]
	ATG12	Unknown	Unknown	Unknown	Unknown	[32]
CREBBP	STX17	K219, K223	HDAC2	Inhibits autophagosome -lysosome fusion	Inhibits the interaction between STX17 and SNAP29	[6]
KAT5/TIP60/Esa1	ULK1	K162, K606	Unknown	Promotes autophagy initiation	Increases the activity of ULK1 complex	[5]
	Atg3	K19, K48, K183	Rpd3	Promotes Atg8 lipidation	Increases the interaction between Atg3 and Atg8	[8]
	SQSTM1	K420, K435	HDAC6	Promotes cargo assembly	Promotes SQSTM1 binding to ubiquitin and ubiquitinated substrates	[9]
	RUBCNL	K483, K523, K533, K573, K633	Unknown	Promotes autophagosome-lysosome fusion	Promotes the interaction of RUBCNL with HOPS complex and STX17	[52]
KAT2A/GCN5	ATG7	K338	Unknown	Inhibits LC3 lipidation	Decreases the activity of ATG7	[34]
	TFEB	K116, K274, K279	SIRT1 (K116)	Inhibits transcriptional regulation of autophagy	Inactivates the transcriptional activity of TFEB	[10,11]
ACAT1	TFEB	K91, K103, K116, K430	SIRT1 (K116)	Promotes transcriptional regulation of autophagy	Activates the transcriptional activity of TFEB	[10,12]
KAT8/MOF	Histone H4	K16	SIRT1	Inhibits transcriptional regulation of autophagy	Inhibits the transcription of autophagy-related genes	[62]

*Many of the listed sites need further rigorous validation to be defined as target sites of the acetyltransferases and deacetylases