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Integrated deep-learning-based mRNA optimization (iDRO) pipeline and model details. (A) iDRO pipeline. iDRO has two main stages (gray blocks), ORF optimization and UTR generation. (B) Network structure of iDRO. Arrows shows the information flow. BiLSTM and RNA-Bart are detailed in sub-figures C and D. (C) Structure of BiLSTM-CRF. (D) Structure of RNA-Bart.
