Table 1.
Input parameters and output information generated for the implementation of Scenario 1 described in the text
| Scenario 1 analysis framework | ||||||||
|---|---|---|---|---|---|---|---|---|
| Step1 | Step 2 | Step 3 | ||||||
| Input | Pathogen selection | Proteins used | Reference network | NET scoring methodology | Edges to keep | Drug screening methodology | Drug scoring methodology | Drugs to keep |
| HIV-1 | All available | Based on host protein | TaxScore Equation (1) |
10 | 5a | 4PH-fold & 8-folda | 30 | |
| Output | Identified proteins | Pathogen connections identified | Total top-scored candidate drugs | |||||
| Host | Pathogen | 10 | 120 b | |||||
| 904 | 65 | |||||||
a
One of the five combinations of options used in this scenario to generate four lists of top-scored drugs (Common/4PH-Fold; V1-Prot/4PH-Fold; V2-Prot/8-fold; V2-Host).
b
Total number of candidate drugs from all four lists.