Table 3.
Table shows the input (tools and options used) and output information generated by the Vir2Drugtool
| Scenario 3 analysis framework | ||||||||
|---|---|---|---|---|---|---|---|---|
| Step1 | Step 2 | Step 3 | ||||||
| Input | Pathogen selection | Proteins used | Reference network | NET scoring methodology | Edges to keep | Drug screening methodology | Drug scoring methodology | Drugs to keep |
| Unspecified | CDK1 (P06493) | Based on host proteins | GenScore Equation (1) |
0 (unlimited) | 3a | 4PH-fold | 30 | |
| Output | Identified proteins | Pathogen connections identified | Total top-scored candidate drugs | |||||
| Host | Pathogen | 16 | 35 b | |||||
| 1 | 1 | |||||||
a
These options are one of the five combinations of options used in this scenario to generate two lists of top-scored drugs (V1-Host/4PH-Fold; V2-Host/4PH-Fold).
b
Total number of candidate drugs from all two lists.