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Blockage of CTLA-4 pathway by anti-CTLA-4: CTLA4 present on the T-cell and bound to B7-1/B7-2 of Antigen Presenting Cells (APC), though the higher expression of CTLA4 on T-cells results in inactivated T-cells and tumor growth continue. When anti-CTLA-4 was introduced, it bound to CTLA4 on the surface of T cells
