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. 2022 Nov-Dec;36(21-24):1100–1118. doi: 10.1101/gad.349930.122

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© 2022 Pekarek et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Oxtr KO in abGCs results in lower frequency of mEPSCs. (A) Schematic diagram of lentiviral injections into Oxtr^fl/fl animals. (B) Representative coronal slice 4 wk after lentiviral RMS injection. Scale bar, 150 μm. (C) Representative miniature excitatory postsynaptic current trace of Oxtr KO and Oxtr Flox/WT cells. (D) Frequency of miniature excitatory postsynaptic current. Students t-test P < 0.05. N_{Oxtr KO} = 6 animals, N_{Oxtr KO} = 12 cells, N_WT = 7 animals, N_WT = 20 cells. (E) Interevent interval graph. Kolmogorov-Smirnov test, P < 0.0001. N_{Oxtr KO} = 6 animals, N_{Oxtr KO} = 11 cells, N_WT = 7 animals, N_WT = 10 cells. (F) Graph of miniature excitatory postsynaptic current amplitude. Students t-test, P > 0.05. N_{Oxtr KO} = 6 animals, N_{Oxtr KO} = 14 cells, N_WT = 7 animals, N_WT = 14 cells.