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. 2022 Dec 6;11(23):e027538. doi: 10.1161/JAHA.122.027538

Figure 1. Efficiency of ERK2 deletion and characteristics of EE2KO mice.

Figure 1

A, Immunohistochemistry of the aorta with an anti‐ERK2 antibody. Scale bar, 25 μm. B, Western blotting of tissues with an anti‐ERK antibody. C, Study protocols. D, Photographs of 30‐week‐old ND‐ or HFHSD‐fed control and EE2KO mice. Scale bar, 10 mm. BW and BP are assessment of body weight and blood pressure. BP indicates blood pressure; BW, body weight; EE2KO, endothelial‐specific extracellular signal‐regulated kinase 2 knockout; ERK, extracellular signal‐regulated kinase; HFHSD, high‐fat/high‐sucrose diet; ipGTTs, intraperitoneal glucose tolerance tests; ITT, insulin tolerance tests; and ND, normal diet.