Table 1.
Composition of the ND and HFHSD Groups
| ND (CE‐7) | HFHSD (F2HFHSD) | |||
|---|---|---|---|---|
| g/100 g | kcal, % | g/100 g | kcal, % | |
| Total calories | 343 kcal | 481 kcal | ||
| Protein | 17.7 g | 20.6 | 20.7 g | 17.2 |
| Fat | 3.8 g | 10 | 29.1 g | 54.5 |
| Carbohydrate | 59.4 g | 69.4 | 34.0 g | 28.3 |
Ingredients: casein 25%, cellulose 5%, a‐corn starch 14.869%, sucrose 20%, vitamin mix (American Institute of Nutrition [AIN]‐93) 1%, mineral mix (AIN‐93G) 3.5%, beef tallow 14%, choline bitartrate 0.25%, tert‐butylhydroquinone 0.006%, lard 14%, soybean oil 2%, L‐cysteine 0.375%. Data represent mean±SEM. (Controls on ND, n=11; EE2KO on ND, n=9; controls on HFHSD, n=11; EE2KO on HFHSD, n=9). EE2KO indicates endothelial‐specific extracellular signal‐regulated kinase 2 knockout; HFHSD, high‐fat/high‐sucrose diet; and ND, normal diet. *P<0.05 vs corresponding ND. **P<0.01 vs corresponding ND. † P<0.05 vs controls with HFHSD. ‡ P<0.01 vs controls with HFHSD.