Table 1.
Subject Characteristics within Nontuberculous Mycobacteria Clusters
| General Demographics | |
|---|---|
| Total patients | 27 |
| Females, n (%) | 18 (66.6) |
| Average age, yr | 38.48 |
| Race | |
| White | 25 |
| Unknown/decline to answer | 2 |
| Ethnicity, n (%) | |
| Non-Hispanic | 24 (88.8%) |
| Hispanic | 1 (3.7%) |
| Unknown/decline to answer | 2 (7.4%) |
| Clinical descriptives | |
| Mutation, n (%) | |
| F508del:F508del | 11 (40.7%) |
| F508del:other | 13 (48.1%) |
| Other than F508del | 3 (11.2%) |
| Average of CF centers visited by subjects, n (range) | 1.4 (1–3) |
| Clinic visits per subject, n (range)* | 9.4 (3–18) |
| Admissions, n (range)* | 2.9 (0–18) |
| Subjects on NTM treatment, n (%) | 19 (70.3) |
| Subjects with ATS NTM criteria, n (%) | 15 (55.5) |
| Patients with known CF contact, n (%) | 2 (7.4) |
| Deceased by the end of study, n (%) | 4 (14.8) |
| Females, n (%) | 2 (50) |
| Average age, n (range) | 39.5 (25–79) |
| Cause of death | |
| Respiratory/cardiorespiratory | 2 (50) |
| Liver disease/liver failure | 1 (25) |
| Unknown | 1 (25) |
| Subjects with Mycobacterium abscessus | 3 (75) |
| Subjects with M. avium | 1 (25) |
| Number of clusters, n (%) | 11 |
| M. abscessus clusters | 6 (54.5) |
| Clusters in the dominant circulating clone | 3† |
| M. abscessus ssp. massiliense clusters | 1 (9.09) |
| M. avium | 2 (18.2) |
| M. intracellulare | 2 (18.2) |
| Number of patients in a cluster, average (range) | 2.45 (2–4) |
| Total overlap clinics | |
| Clinic | 6 |
| Admissions | 6 |
| Length of admission overlap in d, average (range) | 13.16 (5–17) |
Definition of abbreviations: ATS = American Thoracic Society; CF = cystic fibrosis; NTM = nontuberculous mycobacteria.
*
During the extraction range period, per cluster.
†
Fifty percent of the M. abscessus clusters.