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. 2023 Jan 19;18(1):e0279029. doi: 10.1371/journal.pone.0279029

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© 2023 Luo et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — The pathway is obtained from KEGG pathway and confirmed through NCBI PubMed. The target genes involved in LTP and LTD were predicted with at least two of the following databases: miRDB, miRanda, miRWalk, TargetScan, DIANA-mirPath, and miRNA.org. ER: endoplasmic reticulum; AMPAR: glutamate ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor; CaMKII: Calcium/calmodulin-dependent protein kinase II; CaMKIV: Calcium/calmodulin-dependent protein kinase IV; CREB: cAMP responsive element binding protei; ERK1/2: extracellular signal-regulated kinase; G: guanine nucleotide binding protein (G protein); Gq: guanine nucleotide binding protein q polypeptide; IP3R: Inositol 1,4,5-triphosphate receptor; MEK1/2: mitogen-activated protein kinase; mGLUR: metabotropic glutamate receptor; NMDAR: N-methyl-D-aspartate receptor; PLCβ4: Phospholipase Cβ4; PLA2: Phospholipase A2; PKC: protein kinase C; Rap1: RAS related protein 1; PKA: protein kinase A; RSK: ribosomal protein S6 kinase.