Association of baseline variables with palbociclib discontinuation and dose reduction to 100 mg. Individual forest plots can be found in the Data Supplement. AI, aromatase inhibitor: ECOG, Eastern Cooperative Oncology Group; ET, endocrine therapy; G, grade; HR, hazard ratio; PgR, progesterone receptor; Tis, carcinoma in situ; Tx, primary tumor cannot be assessed.