TABLE 5.
Association Between Daily Biomarker Measures and Delirium Severity (Confusion Assessment Method for the ICU-7) Observed the Following Day for Those Without Coma or Delirium at First Assessment in ICU (n = 50)a
| Variable | C-Reactive Protein | d-Dimer | Ferritin | |||
|---|---|---|---|---|---|---|
| Estimate se | p | Estimate se | p | Estimate se | p | |
| Age | 0.002 (0.01) | 0.903 | 0.004 (0.01) | 0.767 | 0.005 (0.01) | 0.732 |
| Race | ||||||
| White | 0.44 (0.81) | 0.586 | 0.49 (0.77) | 0.525 | 0.37 (0.79) | 0.636 |
| Black | –0.51 (0.73) | 0.489 | –0.46 (0.68) | 0.505 | –0.62 (0.71) | 0.387 |
| Hispanic | –0.09 (0.77) | 0.910 | –0.16 (0.72) | 0.825 | –0.24 (0.75) | 0.752 |
| Other (reference) | 0.00 | 0.00 | 0.00 | |||
| Sex | ||||||
| Male | 0.08 (0.37) | 0.825 | –0.16 (0.34) | 0.629 | 0.04 (0.36) | 0.919 |
| Severity of illness and comorbidities | ||||||
| Acute Physiology and Chronic Health Evaluation-II | 0.10 (0.02) | < 0.001 | 0.09 (0.02) | < 0.001 | 0.12 (0.02) | < 0.001 |
| Charlson Comorbidity Index | 0.15 (0.10) | 0.154 | 0.14 (0.10) | 0.138 | 0.12 (0.10) | 0.226 |
| Mechanical ventilation | 2.75 (0.41) | < 0.001 | 2.82 (0.36) | < 0.001 | 2.78 (0.41) | < 0.001 |
| Hypertension | –1.19 (0.44) | 0.010 | –1.26 (0.42) | 0.005 | –1.10 (0.45) | 0.018 |
| Time, d | 0.22 (0.05) | < 0.001 | 0.23 (0.05) | < 0.001 | 0.20 (0.05) | < 0.001 |
| Time period | 1.95 (0.82) | 0.019 | 2.35 (0.76) | 0.002 | 1.91 (0.85) | 0.025 |
| Biomarker quartile | 0.24 (0.10) | 0.017 | 0.13 (0.12) | 0.278 | 0.22 (0.12) | 0.066 |
| Interaction (time [d]a period of first 7 d vs second 7 d) | –0.28 (0.09) | 0.003 | –0.37 (0.09) | < 0.001 | –0.28 (0.10) | 0.004 |
a
Mixed-effects models adjusting for Acute Physiology and Chronic Health Evaluation-II calculated on day of coma/delirium assessment.