TABLE 5.
Three-year-old liver histopathology reads comprising NAS
| Maternal diet: | CD | CD | WSD | WSD | p values (ANOVA) | |||
|---|---|---|---|---|---|---|---|---|
| Postweaning diet: | CD | WSD | CD | WSD | mWSD | pwWSD | INT | Sex |
| n | 15–16 | 6 | 23–24 | 8 | ||||
| Sex (male/female) | ||||||||
| Steatosis | 0.35±0.09 | 0±0 | 0.19±0.06 | 0±0 | 0.23 | <0.0005 | 0.19 | 0.38 |
| Lobular inflammation | 0.65±0.12 | 0.67±0.19 | 0.79±0.1 | 0.75±0.19 | 0.41 | 0.93 | 0.69 | 0.10 |
| Hepatocyte ballooning | 0.32±0.09 | 0±0 | 0.24±0.07 | 0.75±0.23 | <0.05 | 0.53 | <0.005 | 0.72 |
| NAS | 1.32±0.16 | 0.67±0.19 | 1.21±0.13 | 1.5±0.24 | 0.05 | 0.32 | <0.05 | 0.56 |
| Fibrosis | 0.68±0.12 | 0.83±0.21 | 0.7±0.1 | 0.81±0.19 | 0.89 | 0.44 | 0.78 | <0.05 |
| Males | 0.91±0.22 | 0.87±0.29 | 0.79±0.12 | 0.87±0.29 | ||||
| Females | 0.52±0.11 | 0.75±0.25 | 0.55±0.14 | 0.75±0.25 | ||||
Data are represented as mean±SEM for both pathologists’ reads together. Two-way ANOVA with effect for maternal (mWSD) and postweaning (pwWSD) diet, interaction (INT), and sex is shown. When sex effect is significant, mean±SEM for the variable, broken down by males and females, is shown.
Abbreviations: CD indicates chow diet; NAS, NAFLD activity score; WSD, Western-style diet. p values in bold indicate significance.