Figure 5.

Assessment of lysosomal distention in the caudal and rostral regions of the cerebral cortex, and the cerebellum. At 6 months post administration of AAVTCM8-coNAGLU, cortex and cerebellum were examined for LAMP1. (A) Detection of LAMP1 (green) was performed in separate representative specimens. (B) Quantification of ROI% positive area in the cortex (rostral), cortex (caudal) and cerebellum shows significant attenuation of lysosomal (LAMP1) signal in IC6 and ICM treated animals. P-values are indicated by * (<0.05), ** (<0.01), ***(<0.0001), **** (<0.00001) or NS (not significant).