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. Author manuscript; available in PMC: 2024 Jan 5.

Published in final edited form as: Int J Pharm. 2022 Nov 24;630:122423. doi: 10.1016/j.ijpharm.2022.122423

Table 2.

Composition of ciprofloxacin hydrochloride ocular inserts according to the I-optimal mixture design.

Formulation code	Run	Composition (% w/w)
Formulation code	Run	HPC JXF	PEO N10	PEG 4000	Sorbitol
F1	1	62.6667	31.3333	0	0
F2	2	0	87	3	4
F3	3	30.3333	61.6667	2	0
F4	4	45.5	45.5	0	3
F5	5	28.3333	56.6667	3	6
F6	6	0	87	1	6
F7	7	0	87	1	6
F8	8	45.5	45.5	0	3
F9	9	66.375	22.375	0.75	4.5
F10	10	0	94	0	0
F11	11	88	0	2	4
F12	12	88	0	0	6
F13	13	94	0	0	0
F14	14	56.6667	28.3333	3	6
F15	15	22.375	69.375	0.75	1.5
F16	16	0	87	3	4
F17	17	42.5	42.5	3	6
F18	18	30.3333	61.6667	2	0
F19	19	91	0	3	0
F20	20	88	0	2	4