Table 3.

HME processing parameters during the fabrication of ciprofloxacin hydrochloride ocular inserts.

Code	Process temperature (°C)	Residence time (min)	Feed rate (g/min)	Screw speed (rpm)	Torque (Ncm)
F1	90	3.36	0.43	50	53
F2	90	3.53	0.33	50	22
F3	90	3.20	0.36	50	28
F4	90	3.41	0.35	50	25
F5	90	4.52	0.42	50	19
F6	90	4.23	0.38	50	20
F7	90	4.23	0.38	50	20
F8	90	3.41	0.35	50	25
F9	90	4.58	0.40	50	26
F10	90	4.36	0.40	50	30
F11	120	4.29	0.44	50	33
F12	120	4.13	0.35	50	43
F13	140	3.44	0.36	50	66
F14	90	4.38	0.39	50	25
F15	90	4.39	0.38	50	27
F16	90	3.53	0.36	50	22
F17	90	4.22	0.41	50	19
F18	90	3.20	0.36	50	28
F19	140	3.33	0.42	50	21
F20	140	4.29	0.44	50	33