Table 4.

Generated trial formulations and their observed responses according to the mixture design.

Code	Run	Response (%)		Code	Run	Response (%)
		Release at 0.5 h	Release at 6 h			Release at 0.5 h	Release at 6 h
F1	1	45.8	100	F11	11	29.6	80.8
F2	2	82.2	90.1	F12	12	35.2	85.0
F3	3	80.1	100	F13	13	19.2	64.5
F4	4	59.4	100	F14	14	69.4	100
F5	5	82.0	100	F15*	15	86.9	100
F6	6	83.1	100	F16	16	82.2	90.1
F7	7	83.1	100	F17	17	72.9	100
F8	8	59.4	100	F18	18	80.1	100
F9	9	49.6	99.9	F19#	19	25.8	63.0
F10	10	81.8	100	F20	20	29.6	80.8

^*,#F15 and F19 are the immediate-release and optimized sustained-release formulations, respectively.