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Criteria of variables and responses for the optimization step.
| Variable | Goal | Lower limit | Upper limit |
|---|---|---|---|
| A: HPC | in range | 0 | 94 |
| B: PEO | in range | 0 | 94 |
| C: PEG 4000 | in range | 0 | 3 |
| D: Sorbitol | in range | 0 | 6 |
| R1: Release at 0.5 h | target = 25 | 20 | 30 |
| R2: Release at 6 h | target = 60 | 55 | 65 |
