Table 2.
Hemolysis Values and Therapeutic Indices for the most effective gram-positive antibacterials and most effective broad spectrum antibacterial.[a]
| Compound | HD20 | E. faecium TI | E. faecalis TI | MRSA TI | A. baumannii TI | E. coli TI |
|---|---|---|---|---|---|---|
| 4B | 9.69 μg/mL | - | 16 | 8 | - | - |
| 4C | 10.1 μg/mL | 8 | 16 | 8 | - | - |
| 4D | 10.6 μg/mL | 8 | 16 | 8 | - | - |
| 5B | 10.1 μg/mL | - | 16 | 8 | - | - |
| 5C | 10.6 μg/mL | 8 | 16 | 8 | - | - |
| 5D | 11.0 μg/mL | 8 | 16 | 8 | - | - |
| 7A | 85.6 μg/mL | 63 | 63 | 63 | - | - |
| 7E | 357 μg/mL | 63 | 125 | 63 | - | - |
| 10A | 85.1 μg/mL | - | 63 | 31 | - | - |
| 10E | 91.1 μg/mL | 31 | 63 | 16 | - | - |
| 10H | 46.2 μg/mL | 8 | 8 | 8 | 4 | 2 |
[a]
Hemolysis values were calculated with defibrinated sheep blood and reported as Lysis20 values which refer to 20% cell lysis compared to the Triton X control.