Fig. 1 |. SARS-CoV-2–human protein interactome.

a, Pipelines using Y2H and AP–MS for detecting SARS-CoV-2–human protein–protein interactions. b, Edges between viral proteins (diamonds) and human proteins (circles) represent protein–protein interactions. Edge colors indicate the methods used to detect the protein–protein interaction. Several biological processes that are significantly enriched in these human proteins (Supplementary Fig. 2 and Supplementary Table 2) are highlighted with yellow background. Human proteins that interact with only one SARS-CoV-2 protein are shown in the box connected to that specific protein. The interactome can be found in Supplementary Table 1.