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. Author manuscript; available in PMC: 2023 Jan 20.
Published in final edited form as: Nat Biotechnol. 2022 Oct 10;41(1):128–139. doi: 10.1038/s41587-022-01474-0

Extended Data Fig. 4 |. Carvedilol indirectly targets the SARS-CoV-2 host factors through protein-protein interactions with its targets.

Extended Data Fig. 4 |

(a) Individual target-level network proximities to the SARS-CoV-2 gene sets (all host factors, host factors for each viral protein and gene sets by different functions from Reactome). Network proximities were computed using the ‘shortest’ method (See Methods). (b) Potential mechanisms-of-action of carvedilol by exploring the protein-protein interactions of its targets and the SARS-CoV-2 host factors.