Table 2.
Comparison of neurocognitive performance between preschool children with sickle cell disease and healthy matched controls
| SCD Patients | Controls | ||||||
|---|---|---|---|---|---|---|---|
| Measure | Score | Mean (SD) | Mean (SD) | Absolute Mean Difference (95% CI) | Cohen’s D | t | p |
| SB-5a | Working Memory | 91.71 (13.65) | 96.74 (13.36) | 5.03 (1.49, 8.57) | 0.32 | −2.8 | 0.0056 |
| BBCS-3:R a | School Readiness | 89.0 (16.70) | 95.47 (16.42) | 6.47 (2.08, 10.87) | 0.39 | −2.9 | 0.0041 |
| BRIEF-P b | Working Memory | 55.95 (12.95) | 51.37 (12.03) | 4.58 (1.28, 7.89) | 0.37 | 2.73 | 0.0068 |
| BRIEF-P b | Global Executive function | 51.9 (13.66) | 47.43 (11.54) | 4.47 (1.18, 7.76) | 0.35 | 2.68 | 0.0079 |
SCD, sickle cell disease; SD, standard deviation; SB-5, Stanford-Binet Intelligence Scales – Fifth Edition; BBCS-3:R, Bracken Basic Concept Scale – 3rd Edition: Receptive; BRIEF-P, Behavior Rating Inventory of Executive Function – Preschool.
Performance measures included the Stanford-Binet Intelligence Scales – Fifth Edition and the Bracken Basic Concepts Scale – Third Edition: Receptive. Parent ratings of executive functioning collected using the Behavior Rating Inventory of Executive Function – Preschool Version.
Displayed values are Standard Scores with a mean of 100 and standard deviation of 15. Higher scores are indicative of better performance
Displayed values are T Scores with a mean of 50 and standard deviation of 10. Higher scores are indicative of greater symptoms (i.e., more problems)