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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Immunol Rev. 2022 Nov 18;313(1):376–401. doi: 10.1111/imr.13164

Table 1.

Non-convertase directed regulators of complement activation (reproduced from reference 23)

Regulator Function regulated
pathway		 main regulatory
compartment
C1 inhibitor (C1-INH) Inactivates C1r and C1s, MASP-1 and MASP-2 CP/LP fluid
sMAP Binding to MBL, competition with MASPs LP fluid
MAP-1 Binds to MBL/ficolins, LP fluid
Vitronectin (S protein) Binds to C5b-7/8/9 TP (MAC formation) fluid
Clusterin Binds to C5b-7/8/9 TP (MAC formation) fluid
CD59 Binds to C8 and C9 TP (MAC formation) surface