Table 3.
List of secreted proteins released by proteolytic cleavage dependent on tissue strain level. Columns group secreted proteins released by individual enzyme from samples in the lower half of mechanical strains, samples in the upper half of mechanical strains, or samples in both. Proteins listed were detected only in the enzyme treated samples, i.e., proteins also detected in the respective control samples are not included in the list.
| CatK | MMP1 | MMP8 | MMP9 | |||||
|---|---|---|---|---|---|---|---|---|
| DETECTED ONLY UNDER LOW TISSUE STRAIN | ||||||||
| ICOS | ACAN | ACE | COL4A2 | KLKB1 | A2M | LIPH | ||
| LAMA4 | ADNP | ADAMTSL4 | DEFB106 | LAMA1 | ACTN4 | MNDA | ||
| F5 | AFP | EFEMP1 | LAMB1 | ARHGAP9 | MSR1 | |||
| FBN2 | ALDOC | ENTPD5 | LILRA3 | CD47 | MUC5B | |||
| GPC1 | AOC1 | F2 | LPA | CHI3L1 | PSMD7 | |||
| PDCD6IP | APOC3 | FAN1 | LRRC7 | CLCA3P | RELN | |||
| PIGR | APOE | FBN2 | NCAM1 | CPAMD8 | RETN | |||
| RBP3 | ARSA | FGFR4 | PDCD6IP | CPB2 | SEMA6B | |||
| REN | C1QA | GPC1 | PIP | FGF2 | SEMA7A | |||
| VWF | CAP1 | HAUS3 | PRTN3 | FNDC1 | ||||
| WNT10A | CD274 | HSP90AB1 | QSOX1 | FRAS1 | ||||
| CFHR2 | HYOU1 | SEMA | FREM2 | |||||
| CHADL | IGKC | SLC12A1 | HSPA8 | |||||
| COL1A2 | IGKV2-40 | TNXA | IGHG4 | |||||
| COL3A1 | IL17B | WNT10A | LAMA1 | |||||
|
| ||||||||
| DETECTED ONLY UNDER HIGH TISSUE STRAIN | ||||||||
| C1R | ADAM23 | HDLBP | GALNT1 | ACTR10 | LYG1 | QSOX2 | ||
| COL6A1 | AHNAK | HSP90AB1 | SFTPD | BRPF3 | MERTK | ROCK1 | ||
| COL6A3 | C1orf54 | HYOU1 | SST | CCT8 | NPHP3 | SERPINC1 | ||
| DHRS7C | COL16A1 | LAMA1 | CKB | OLFML2A | SETX | |||
| GLG1 | COL19A1 | LAMA2 | COL1A2 | PLA2G3 | TGFB1 | |||
| DNAH5 | LTBP3 | COL5A1 | PLG | TSPEAR | ||||
| DOCK2 | RAB11A | CORIN | QSOX1 | |||||
| F10 | SEMA6D | DNAJC3 | GARS1 | |||||
| FGFR4 | SERPINB6 | DOCK2 | HSP90AA1 | |||||
| FLNA | SERPINC1 | DST | IL4R | |||||
| FRAS1 | THBS4 | F9 | JHY | |||||
| GDI2 | UNC13D | FBN3 | KERA | |||||
| HAUS3 | FNDC5 | LAMC3 | ||||||
|
| ||||||||
| DETECTED UNDER BOTH LOW AND HIGH TISSUE STRAIN | ||||||||
| COL1A2 | APOLD1 | SLC12A1 | ACAN | A1BG | DEFA1 | MAPT | ||
| FMOD | CD274 | TUBB4B | AHNAK | ADAM28 | EMILIN2 | MVP | ||
| GDF9 | CHADL | APOB | ADM2 | EPHB4 | NIT2 | |||
| WNT6 | COL1A2 | APOLD1 | AFM | FAP | ODAD4 | |||
| COL8A1 | CYRIB | ARSG | FERMT3 | PON3 | ||||
| CYRIB | LYG1 | CALML5 | FGFR4 | PZP | ||||
| DST | NIT2 | CAT | FIBIN | SDCBP | ||||
| HSPA8 | ODAD4 | CD200R1 | GALNT1 | SEMA3F | ||||
| IL17B | PLG | CD274 | GDI2 | SERPINB13 | ||||
| LAMB1 | SERPINB13 | CES4A | GSDMD | SLC12A1 | ||||
| LTBP1 | CFAP43 | HSP90AB1 | SORL1 | |||||
| LYG1 | CFI | HUWE1 | SPINT1 | |||||
| NIT2 | CHADL | IL17B | SST | |||||
| PLG | COL28A1 | LAMA2 | UNC13D | |||||
| QSOX1 | COL4A3 | LOX | VWF | |||||
| SERPINB13 | CYRIB | LRIG3 | WNT10A | |||||