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. Author manuscript; available in PMC: 2024 Jan 18.
Published in final edited form as: J Am Chem Soc. 2022 Dec 28;145(2):1292–1300. doi: 10.1021/jacs.2c11226

Figure 2: PLY-DNA-origami produces transmembrane nanopores that facilitate the diffusion of macromolecules into GUVs.

Figure 2:

Shown from left to right are the schematics and representative images of GUVs 20 minutes after adding buffer only, anti-handle-conjugated PLY, PLY-DNA rings, and DNA-origami rings without PLY. Pseudo-colors: Cyan = Cy3 (DNA ring), red = Cy5 (GUV), and green = FITC (dextran). Scale bars: 5 μm. Bar graphs at the bottom denote the percentages of GUVs with observable dextran influx.