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. 2023 Jan 9;49(1):50–61. doi: 10.1007/s00134-022-06937-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — The use of TILs adopted (panel A, B, C) and the specific extreme treatment (panel D, E, F) in patients with acute brain injury at days 1, 3, and 7. In each plot, the left horizontal bars represent the numbers of patients that are treated with the specific level of TIL (panel A, B, C) or the specific eTIL (panel D, E, F); the vertical bars represent the number of subjects that received each specific combination of treatment specified by the filled dots. For instance, in panel A referring to day 1, 2152 (355 + 1655 + 7 + 135) patients received a basic TIL (horizontal green bar), among which 355 patients were treated only with basic TIL, 1665 were treated with basic and mild-moderate TIL, 7 with basic and extreme TIL and 135 were treated with basic, mild-moderate and extreme TIL on day 1 (vertical bars). Abbreviations: TIL therapy intensity level