Table 2.
Results from multivariable Cox (left) and logistic (right) models exploring the association of the maximum TIL over the first week with mortality and unfavourable neurological outcome at 6 months
| Mortality at 6 months | Unfavourable outcome at 6 months (GOSE < 5) | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | OR | 95% CI | p-value | |
| TIL | ||||||
| eTIL (ref) | 1 | |||||
| Mild-moderate | 1.02 | 0.83–1.26 | 0.858 | 0.95 | 0.89–1.01 | 0.079 |
| No-basic | 1.61 | 1.24–2.09 | < 0.001 | 0.94 | 0.87–1.01 | 0.088 |
| ICPm vs no-ICPm | 0.70 | 0.61–0.82 | < 0.001 | 1.02 | 0.98–1.06 | 0.350 |
| GCS ≤ 8 vs GCS > 8 | 1.48 | 1.18–1.87 | 0.001 | 1.12 | 1.06–1.19 | < 0.001 |
| Age, year | 1.02 | 1.02–1.03 | < 0.001 | 1.01 | 1.01–1.01 | < 0.001 |
| Pupils | ||||||
| Both reactive (ref) | 1 | |||||
| One unreactive | 1.28 | 1.03–1.59 | 0.026 | 1.04 | 0.98–1.11 | 0.181 |
| Both unreactive | 2.46 | 2.10–2.87 | < 0.001 | 1.22 | 1.16–1.28 | < 0.001 |
| Highly pathological CT scan vs normal | 1.78 | 1.49–2.11 | < 0.001 | 1.09 | 1.04–1.14 | < 0.001 |
| Neuroworsening vs no | 2.68 | 2.32–3.09 | < 0.001 | 1.19 | 1.14–1.24 | < 0.001 |
| Pathologies | ||||||
| TBI (ref) | 1 | |||||
| SAH | 0.74 | 0.60–0.90 | 0.003 | 0.97 | 0.91–1.02 | 0.209 |
| ICH | 1.25 | 1.07–1.46 | 0.006 | 1.13 | 1.08–1.19 | < 0.001 |
CI Confidence Interval, CT computed tomography, GCS Glasgow Coma Scale, GOSE Glasgow Outcome Scale Extended, HR Hazard Ratio, ICH intra cranial hemorrhage, OR, Odds Ratio, , SAH subarachnoid hemorrhage, TBI traumatic brain injury, TIL Therapy Intensity level, ICPm patients monitored with intracranial pressure; Highly pathological CT scan Defined as Marshall classification 3 or more (for patients with TBI), Fisher grade 3 or more (for patients with subarachnoid haemorrhage), or intracranial haemorrhage volume 30 mL or more (for patients with intracranial haemorrhage)