Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 1;482(1):131–145. doi: 10.1007/s00428-022-03460-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — B-PLL. An 84-year-old man presented with marked leukocytosis and anemia. Splenomegaly and mesenteric and retroperitoneal lymphadenopathy was found. The white cell differential showed 82% prolymphocytes. Flow cytometry showed a kappa-restricted B-cell population expressing CD19 and bright CD20 lacking CD5, CD10, CD23, and FMC7. FISH for cyclin D1 rearrangement was negative and karyotyping showed no structural evidence of CCND1, CCND2, or CCND3 rearrangement. The blood smear showed numerous prolymphocytes compatible with B-PLL (100 ×). In current practice, a case with this type of morphology would require FISH studies to exclude CCND1, CCND2, and CCND3 rearrangements