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Features of conventional MCL (cMCL) and leukemic non-nodal MCL (nnMCL). Data from [64]
| Feature | cMCL | nnMCL |
|---|---|---|
| Translocations | CCND1, CCND2 or CCND3 | CCND1, CCND2 or CCND3 |
| Lymphadenopathy | Yes | No/minimal |
| SOX11 + | Yes | No/minimal |
| IGHV mutations | No/limited | Yes |
| Genomic complexity | High | Low |
| ATM aberration | Frequent (40–50%) | No |
| CCND1 mutation | No | Yes |
| TP53 aberrations | 15–20% | 20–30% |
