Table 4.
Cox regression analyses, all patients
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender | ||||
| Female | Reference | |||
| Male | 1.15 (0.86–1.51) | 0.35 | ||
| Weight (kg) | 0.95 (0.93–0.96) | < 0.001 | a | |
| Age at operation (y) | 0.87 (0.84–0.89) | < 0.001 | a | |
| Conduit type | ||||
| Pulmonary homograft | Reference | Reference | ||
| Aorta homograft | 3.17 (2.30–4.37) | < 0.001 | 1.43 (0.95–2.16) | 0.09 |
| BJV graft | 2.04 (1.36–3.05) | 0.001 | 1.27 (0.79–2.04) | 0.33 |
| Conduit number | ||||
| First | Reference | Reference | ||
| Second | 0.63 (0.44–0.90) | 0.01 | 0.49 (0.28–0.85) | 0.01 |
| Third/Fourth | 0.53 (0.23–1.20) | 0.13 | 0.29 (0.08–1.00) | > 0.05 |
| Diagnosis | ||||
| PA/VSD | Reference | Reference | ||
| TOF | 0.48 (0.29–0.78) | 0.003 | 1.44 (0.50–4.17) | 0.50 |
| TA | 1.91 (1.31–2.79) | 0.001 | 2.17 (1.24–3.83) | 0.01 |
| TGA/VSD/PS | 1.87 (1.17–3.00) | 0.009 | 3.31 (1.88–5.82) | < 0.001 |
| PS, PI, PA/IVS | 0.36 (0.14–0.90) | 0.03 | 1.61 (0.40–6.44) | 0.50 |
| AS, AI | 0.28 (0.10–0.77) | 0.01 | 1.26 (0.32–5.04) | 0.74 |
| All others d | 1.11 (0.68–1.80) | 0.67 | 1.91 (1.10–3.30) | 0.02 |
| Previous cardiac operation | 0.35 (0.26–0.48) | < 0.001 | 0.48 (0.28–0.83) | 0.01 |
| Number of previous cardiac operations | 1.76 (1.54–2.01) | < 0.001 | 2.32 (1.88–2.87) | < 0.001 |
| Conduit diameter (mm) | 0.80 (0.77–0.83) | < 0.001 | 0.87 (0.80–0.95) | 0.001 |
| Graft Z-Score | 1.28 (1.09–1.52) | 0.003 | 1.02 (0.83–1.25) | 0.84 |
| RV systolic pressure after repair (mmHg) | 1.01 (1.00–1.02) | 0.02 | 0.99 (0.98–1.01) | 0.33 |
| Narrow pulmonary artery | 1.29 (0.81–2.05) | 0.28 | ||
| Proximal hood | 2.15 (1.60–2.89) | < 0.001 | 0.87 (0.56–1.34) | 0.53 |
| Proximal hood type | b | |||
| Ascending aorta | Reference | |||
| Pulmonary homograft patch | 0.45 (0.24–0.85) | 0.01 | ||
| BJV graft patch | 0.58 (0.21–1.60) | 0.29 | ||
| PTFE patch | 0.43 (0.16–1.18) | 0.10 | ||
| Autologous pericardial patch | 2.02 (0.92–4.44) | 0.08 | ||
| Dacron patch | 0.69 (0.40–1.18) | 0.18 | ||
| Bovine pericardial patch | 0.00 (0.00-inf) | 0.96 | ||
| Anatomic graft position | 0.31 (0.22–0.45) | < 0.001 | 1.11 (0.42–2.90) | 0.83 |
| Previous homograft | 0.61 (0.42–0.89) | 0.01 | c | |
| Previous BJV graft | 0.71 (0.26–1.93) | 0.51 | ||
aCorrelated with conduit diameter
bRemoved due to small number of operations (n = 199)
cCorrelated with conduit number
dIncluded diagnoses: ALCAPA, CCTGA, DORV, IAA, TGA
ALCAPA anomalous origin of left coronary artery from pulmonary artery, AI aortic insufficiency, AS aortic stenosis, BJV bovine jugular vein, CCTGA congenitally corrected transposition of the great arteries, DORV double-outlet right ventricle, IAA interrupted aortic arch, IVS intact ventricular septum, PA pulmonary atresia, PI pulmonary insufficiency, PS pulmonary stenosis, PTFE polytetrafluoroethylene, TA truncus arteriosus, TGA transposition of the great arteries, TOF tetralogy of Fallot, VSD ventricular septal defect