. 2022 Dec 2;60(2):293–304. doi: 10.1007/s00592-022-02001-y

Table 2.

ORs with 95% CIs for the associations between 25(OH)D concentrations and T2DM in women and men. The Tromsø Study 1986–2016

		T1 (1986/87)		T2 (1994/95)		T3 (2001)		T4 (2007/08)		T5 (2015/16)
		Crude	Adjusted^a	Crude	Adjusted^a	Crude	Adjusted^a	Crude	Adjusted^a	Crude	Adjusted^a
Biomarker	Sex	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
25(OH)D (per 5-nmol/l increase)	Women	0.97 (0.86, 1.10)	1.00 (0.87, 1.15)	0.93 (0.83, 1.05)	0.97 (0.84, 1.12)	0.77* (0.68, 0.87)	0.79* (0.68, 0.91)	0.79* (0.65, 0.96)	0.79 (0.60, 1.02)	1.01 (0.91, 1.12)	1.06 (0.93, 1.22)
25(OH)D (per 5-nmol/l increase)	Men	1.12* (1.00, 1.26)	1.15* (1.00, 1.31)	1.05 (0.94, 1.18)	1.09 (0.95, 1.26)	0.89 (0.79, 1.01)	0.90 (0.76, 1.07)	1.09 (0.93, 1.28)	1.14 (0.96, 1.35)	1.13 (0.95, 1.35)	1.21 (0.89, 1.65)
25(OH)D (> 50 nmol/l)^b	Women	0.65 (0.32, 1.31)	0.65 (0.30, 1.40)	0.64 (0.32, 1.28)	0.75 (0.35, 1.70)	0.24* (0.12, 0.50)	0.29* (0.13, 0.69)	0.33* (0.12, 0.87)	0.25 (0.06, 1.03)	1.84 (0.27, 2.62)	1.03 (0.21, 5.05)
25(OH)D (> 50 nmol/l)^b	Men	2.33* (1.12, 4.87)	2.98* (1.24, 7.17)	0.99 (0.45, 2.17)	1.23 (0.46, 3.25)	0.58 (0.27, 1.21)	0.86 (0.32, 2.30)	2.50 (0.71, 8.84)	3.83 (0.75, 19.4)	2.33 (0.51, 10.8)	23.4 (0.74, 743)

25(OH)D 25-hydroxyvitamin D, CI confidence interval, OR odds-ratio, T time-point

*p value < 0.05

^aAdjusted for age, body mass index, weight change, and physical activity

^b< 50 nmol/l is set as the reference