Table 1.

Diagnostic criteria for accelerated and blast phase chronic myeloid, BCR::ABL1–positive (CML) according to the International Consensus Classification¹

Accelerated phase	Bone marrow or peripheral blood blasts 10–19%	Blast phase	Bone marrow or peripheral blood myeloid blasts ≥ 20%
	Peripheral blood basophils ≥ 20%		Myeloid sarcomab
	Presence of additional clonal cytogenetic abnormality in Ph+ cells (ACA)a		Bone marrow or peripheral blood lymphoid blasts > 5% is consistent with lymphoblastic crisisc

Ph, Philadelphia chromosome

^aSecond Ph, trisomy 8, isochromosome 17q, trisomy 19, complex karyotype ≥ 3 cytogenetic abnormalities, or abnormalities of 3q26.2

^bExtramedullary blast proliferation

^cImmunophenotypic analysis is required to confirm lymphoid lineage