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. 2022 Dec 31;60(2):163–189. doi: 10.1007/s00592-022-02014-7

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Portrait of Leonard Thompson (L.T.). Unknown date and author. University of Toronto Archives. Recorded effects of the administration of Collip's pancreatic extract to L.T., the first diabetic patient successfully treated in the Inpatient Ward of the Department of Medicine, Toronto General Hospital. Left Daily chart record between January 1 and February 20, 1922, of urinary glucose excretion. Right Rapid elimination of ketonuria. Reduction of blood glucose and glycosuria fractionated over 24 h. [79]