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. 2022 Oct 11;482(1):227–244. doi: 10.1007/s00428-022-03414-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — EBV-positive mucocutaneous ulcer. A solitary skin lesion in the forehead of a 70-year-old man without known immunosuppression. A Panoramic view of a well-circumscribed ulcer (snap-shot from scanned slide). B CD3 stain demonstrates abundant reactive T cells that form a rim at the base of the ulcer (snap-shot from scanned slide). C Higher magnification showing Hodgkin and Reed–Sternberg (HRS)-like cells in a polymorphic background. D CD20 stain is positive in the large HRS-like cells and in medium and small B cells. E CD30 stain is strongly positive in the HRS-like cells. F EBER in situ hybridization is positive in the HRS-like cells. Note the wide range of cells positive for EBER. G LMP1 is positive in B cells surrounding a blood vessel (angiocentric lesion). H The LMP1-positive cells are also positive for EBER. (C–H, original magnification, 400×)