Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 11;482(1):227–244. doi: 10.1007/s00428-022-03414-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — EBV-positive diffuses large B cell lymphoma, NOS. A–D Polymorphic variant with numerous HRS-like cells. A Low magnification of a lymph node diffusely infiltrates with geographic areas of necrosis (original magnification, ×50). B EBER in situ hybridization shows diffuse EBV-positive tumor cells surrounding the necrosis (original magnification, ×100). C Polymorphous proliferation characterized by small lymphocytes, plasma cells, histiocytes, and scattered large transformed cells mimicking Hodgkin and Reed–Sternberg (HRS) cells. Insert: the HRS-like cells are LMP1 positive (original magnification, 400×). D The HRS-like cells are strongly CD20 positive. Note the polymorphic B cell infiltrate. E–F Monomorphic type of EBV-positive diffuses large B cell lymphoma, NOS. E The lymph node is diffusely replaced by a monomorphic infiltrate of large centroblastic cells. F EBER in situ hybridization is positive in almost 100% of the tumor cells. (E–F original magnification, ×400)