Table 3.
HLA mismatches, and type and specificities of DSA.
| HLA | DSA+ |
Non-DSA+ |
No HLA Ab- |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blinded (SC) A1 (N = 92) |
Unblinded (BLC) B1 (N = 106) |
Blinded (SC) A2 (N = 391) |
Unblinded (BLC) B2 (N = 427) |
Blinded (SC) C (N = 526) |
Unblinded (BLC) D (N = 495) |
|||||||
| Donor MM N (%): ∗assumed | DSA % [median MFI] | Donor MM N (%) ∗assumed | DSA % [median MFI] | Donor MM N (%) ∗assumed |
DSA % [median MFI] | Donor MM N (%) ∗assumed |
DSA % [median MFI] | Donor MM N (%) ∗assumed |
DSA % [median MFI] | Donor MM N (%) ∗assumed |
DSA % [median MFI] | |
| A | 78 (85%) ∗0 | 26% [3998] | 87 (82%) ∗1 | 15% [3630] | 273 (70%) ∗0 | 0 | 285 (67%) ∗0 | 0 | 402 (76%) ∗0 | 0 | 352 (71%) ∗0 | 0 |
| B | 84 (91%) ∗0 | 9.8% [2424] | 93 (88%) ∗0 | 13% [5990] | 287 (73%) ∗0 | 0 | 300 (70%) ∗0 | 0 | 435 (83%) ∗0 | 0 | 385 (78%) ∗1 | 0 |
| C | 73 (79%) ∗1 | 16% [3733] | 80 (76%) ∗2 | 10% [3401] | 246 (63%) ∗1 | 0 | 258 (60%) ∗1 | 0 | 364 (69%) ∗3 | 0 | 322 (65%) ∗1 | 0 |
| DRB1 | 65 (71%) ∗1 | 6.5% [2645] | 89 (84%) ∗7 | 18% [3155] | 200 (51%) ∗2 | 0 | 220 (52%) ∗2 | 0 | 307 (58%) ∗1 | 0 | 284 (57%) ∗2 | 0 |
| DRB3 | 16 (17%) ∗3 | 4.3% [3148] | 17 (16%) ∗2 | 3.8% [4290] | 38 (9.7%) ∗0 | 0 | 35 (8.2%) ∗0 | 0 | 58 (11%) ∗0 | 0 | 65 (13%) ∗2 | 0 |
| DRB4 | 17 (19%) ∗0 | 2.2% [13850] | 25 (24%) ∗1 | 7.5% [6373] | 42 (11%) ∗1 | 0 | 49 (12%) ∗2 | 0 | 58 (11%) ∗0 | 0 | 82 (17%) ∗0 | 0 |
| DRB5 | 7 (7.6%) ∗0 | 1.1% [53261] | 8 (7.5%) ∗0 | 0.94% [55681] | 28 (7.2%) ∗0 | 0 | 28 (6.6%) ∗0 | 0 | 50 (9.5%) ∗0 | 0 | 49 (9.9%) ∗1 | 0 |
| DQA | 8 (8.7%) ∗2 | 4.3% [12005] | 9 (8.5%) ∗6 | 4.7% [12845] | 9 (2.3%) ∗5 | 0 | 14 (3.3%) ∗2 | 0 | 10 (1.9%) ∗2 | 0 | 8 (1.6%) ∗1 | 0 |
| DQB | 66 (72%) ∗5 | 44% [6947] | 78 (74%) ∗5 | 46% [6279] | 161 (41%) ∗5 | 0 | 189 (44%) ∗6 | 0 | 281 (53%) ∗0 | 0 | 265 (54%) ∗4 | 0 |
| DPB | 11 (12%) ∗5 | 3.3% [5623] | 9 (8.5%) ∗4 | 0.94% [5177a] | 31 (7.9%) ∗15 | 0 | 34 (8%) ∗15 | 0 | 35 (6.7%) ∗6 | 0 | 33 (6.7%) ∗18 | 0 |
Table shows the number and percentage of recruits in each group with a mismatched (MM) HLA on their donor kidney, according to the type of mismatch, HLA class I (A–C) or HLA class II (DRB1-5, DQA, DQB or DPB).
In some cases, a mismatch at 1 locus can be assumed by the strong linkage disequilibrium with other loci. The number of recruits where this happens is represented by ∗. Also shown is the percentage of recruits in each group with a DSA against these HLA, followed by the median mean fluorescence intensity (MFI) of the DSA on Luminex analysis using single antigen beads. More recruits in the blinded group had antibodies against HLA A, whereas more recruits in the unblinded group had antibodies against HLA DRB1 and DRB4.
Only one observation for these values and therefore median is just the observed value.