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. 2022 Nov 29;48(3):459–467. doi: 10.1038/s41386-022-01495-y

Fig. 3. High frequency opto-DBS in D1DR- or D2DR-containing neurons of the accumbens shell did not alter cocaine-primed reinstatement in female rats.

Fig. 3

Time courses show cumulative active lever presses during 1 h reinstatement sessions. Bars show total responding overlaid with active lever presses (circles) and inactive lever presses (triangles) for individual rats, with each rat receiving sham and 130 Hz stimulation in a within-subjects design. In female rats that expressed (A) eYFP (n = 6) or (B) ChR2 (n = 8) in D1DR-containing neurons in the nucleus accumbens shell, cocaine seeking did not differ when rats received sham stimulation or 130 Hz opto-DBS stimulation throughout the cocaine-primed reinstatement session. In female rats that expressed (C) eYFP (n = 10) or (D) ChR2 (n = 10) in D2DR-containing neurons in the nucleus accumbens shell, cocaine seeking did not differ when rats received sham stimulation or 130 Hz opto-DBS stimulation throughout the cocaine-primed reinstatement session. Inactive lever presses for one rat expressing ChR2 in D2DR-containing neurons were 273 in the sham test session; this data point was included in the analyses but omitted from the figure for scale.