Table 2a.
Group differences of kynurenine metabolites or ratios (ANCOVA) with age, gender and current psychotropic medication use as cofactors.
| Controls (n = 185) |
BD acute (n = 205) |
BD stable (n = 116) |
SCZ acute (n = 111) |
SCZ stable (n = 75) |
|||
|---|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | F | FDR P-value | |
| TRP (uM) N = 591 | 63.22 (13.09) | 54.85 (17.03) | 58.85 (18.66) | 59.87 (17.52) | 65.66 (17.73) | 6.91 | .001 |
| KYN (uM) N = 591 | 2.43 (.55) | 2.38 (.77) | 2.39 (.74) | 2.19 (.67) | 2.36 (.66) | 3.06 | .002 |
| KA (nM) N = 591 | 68.71 (30.22) | 63.00 (33.87) | 71.86 (32.39) | 56.25 (25.59) | 64.92 (23.73) | 5.71 | <.001 |
| QUINA (nM) N = 591 | 11.43 (5.54) | 8.76 (5.40) | 12.46 (7.24) | 7.60 (3.75) | 11.22 (6.18) | 19.36 | <.001 |
| XA (nM) N = 591 | 314.96 (53.04) | 277.80 (69.39) | 287.16 (60.84) | 288.31 (61.29) | 309.41 (61.64) | 8.92 | <.001 |
| PICO (nM) N = 591 | 58.14 (20.39) | 61.99 (26.57) | 68.68 (29.75) | 64.06 (28.48) | 61.41 (26.49) | 2.48 | .052 |
| QUINO (nM) N = 442 | 101.37 (40.38) | 86.92 (52.04) | 96.49 (46.17) | 75.66 (38.60) | 91.87 (40.59) | 4.93 | .001 |
| KYN/TRP N = 692 | 0.040 (0.011) | 0.046 (0.019) | 0.043 (0.014) | 0.039 (0.017) | 0.038 (0.014) | 5.17 | <.001 |
| KA/KYN N = 692 | 29.42 (14.78) | 28.91 (19.32) | 32.40 (16.94) | 27.07 (13.19) | 29.11 (11.85) | 2.09 | .088 |
| XA/KYN N = 692 | 132.99 (28.17) | 124.88 (38.03) | 126.55 (31.30) | 139.78 (39.42) | 136.79 (29.69) | 3.07 | .022 |
| QUINO/KA N = 522 | 1.96 (1.51) | 1.78 (1.51) | 1.72 (1.53) | 1.80 (1.46) | 1.71 (1.11) | 0.51 | .729 |