Table 3.
Results of the multivariate forward stepwise nested linear regression analysis (with Z scores). For each metabolite separately, only the significant predictors are reported in the table.
| Overall model |
Predictors |
FDR p-value |
||||
|---|---|---|---|---|---|---|
| Z score DOI |
<.001 |
|||||
| Z-score PANSS_pos (Diag cat) |
<.001 |
|||||
| Mood stabilizer use (No = 0/Yes = 1) (Diag Cat) |
.003 |
|||||
| Sex |
.003 |
|||||
| Z score Onset age |
.030 |
|||||
| Diagnostic category (SCZ – BD – CT) |
.210 |
|||||
| For each KP metabolite | PredictorsPredictors | Df | Scaled estimate | Standard error | F ratio | P value |
| TRP |
DOI | 1 | −2.44 | 1.07 | 5.21 | .023 |
| Onset age | 1 | −2.36 | 1.06 | 4.95 | .027 | |
| Mood stabilizer use (0) | 2 | BD: 3.06 | 1.52 | 4.45 | .045 | |
| SCZ: 4.56 |
2.07 |
4.45 |
.028 |
|||
| KYN |
DOI | 1 | 0.18 | 0.04 | 16.93 | <.001 |
| Onset age | 1 | 0.09 | 0.04 | 4.79 | .030 | |
| PANSS_pos | 2 | BD: 0.01 | 0.06 | 2.51 | .910 | |
| SCZ: 0.16 |
0.07 |
2.51 |
.026 |
|||
| XA |
DOI | 1 | −11.93 | 3.90 | 9.34 | .002 |
| Mood stabilizer use (0) | 2 | BD: 16.90 | 5.55 | 6.61 | .003 | |
| SCZ: 15.08 | 7.57 | 6.61 | .048 | |||
| Sex |
1 |
−8.59 |
3.88 |
4.90 |
.028 |
|
| QUINO |
DOI | 1 | 8.74 | 2.89 | 9.18 | .003 |
| Onset Age | 1 | 6.17 | 2.87 | 4.62 | .032 | |
| Sex (F) |
1 |
8.98 |
2.87 |
9.67 |
.002 |
|
| PICO |
DOI |
1 |
3.85 |
1.89 |
4.15 |
.043 |
| KA |
Sex (F) | 1 | −4.19 | 1.81 | 5.38 | .021 |
| PANSS_pos | 2 | BD: 3.08 | 2.38 | 3.01 | .196 | |
| SCZ: 6.04 |
2.96 |
3.01 |
.042 |
|||
| QUINA | Onset age | 1 | 0.83 | 0.37 | 5.08 | .025 |
| Mood stabilizer use (0) | 2 | BD: 1.17 | 0.53 | 2.47 | .027 | |
| SCZ: 0.12 | 0.72 | 2.47 | .866 | |||
| PANSS_pos | 2 | BD: 1.55 | 0.49 | 9.19 | .001 | |
| SCZ: 1.68 | 0.61 | 9.19 | .006 | |||