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. 2022 Nov 23;10(1):111–117. doi: 10.1002/acn3.51707

Figure 1.

Figure 1

Biophysical properties of novel KCNC1 gain of function variants. Wild‐type (WT) or gain of function variants were expressed in HEK‐293T cells and outward delayed‐rectifier potassium currents were recorded via whole‐cell voltage clamp. (A) Representative examples of recording from of Kv3.1‐WT, Met430Ile, Val432Met and Val434Leu. Arrow in WT indicates the tail current upon return from the test potential to −40 mV. (B) Voltage‐dependence of activation presented as current density normalized to peak I K for each variant. (C) Voltage dependence and peak current density of tail currents. (D) Time constant of activation (left) and deactivation (right) at +40 mV.