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. 2022 Nov 23;10(1):111–117. doi: 10.1002/acn3.51707

Figure 2.

Figure 2

Biophysical properties of KCNC1‐WT co‐expressed with KCNC1 variants. WT and variants were co‐transfected in a 1:1 ratio and expressed in HEK‐293T cells, and outward delayed‐rectifier potassium currents were recorded via whole‐cell voltage clamp. (A) Representative examples of recording from of Kv3.1‐WT, WT + Met430Ile, WT + Val432Met and WT + Val434Leu. (B) Voltage‐dependence of activation presented as current density normalized to peak I K for each group. (C) Voltage dependence and peak current density of tail currents. (D) Time constant of activation (left) and deactivation (right) at +40 mV. Note that each WT:variant combination exhibits similar results to variant alone in Figure 1.