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. 2022 Dec 14;10(1):18–31. doi: 10.1002/acn3.51695

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Plasma P‐Tau181 cut point predicts rate of change in cognitive testing, time to functional decline, and time to dementia onset in mild cognitive impairment in the Alzheimer's disease neuroimaging initiative cohort. (A) Effect of p‐tau181 cut point on longitudinal Mini Mental State Examination (MMSE) performance, assessed with linear mixed effects models adjusting for age, sex, and baseline MMSE. Coefficient (β) and p‐values for p‐tau181 cut point*time interaction shown, with time in years. (B) Effect of p‐tau181 cut point on time to a clinically significant decline in the Clinical Dementia Rating Scale Sum of Boxes, (CDR‐SB), equivalent to an increase by 1.5 points or more from baseline, assessed with Cox proportional hazards model. (C) Effect of p‐tau181 cut point on time to conversion to Dementia, assessed with Cox proportional hazards model. Groups are defined as above (red) or below (blue) the p‐tau181 cut point of 3.44 pg/mL.