Fig. 3.

Effect of MPs on viability of human colon organoids. A Fluorescence microscopic images. B TEM. C Fluorescence from MPs and mucin-2 in colon organoids. D % viability changes (with IC₅₀ 13. 0 mg/ml and 59.7 mg/ml for 50 nm and 100 nm MPs, respectively), E dead cells from EtHD-1 staining and F size changes of colon organoids after incubation with 50 and 100 nm MPs. Fluorescence images were taken under magnification × 100. The results are presented as the mean ± S.D. (n = 6). ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. control