Fig. 4.

PCR array results of colon organoids after incubation with 50 nm MPs. Changes in the gene expression of A inflammatory, B apoptosis, C immunity, D metabolism (unfolded protein response), E ECM and adhesion molecules, and F digestive secreted proteins of colon organoids after incubation with 50 nm MPs. G Dot blot results of control and 50 nm MPs-treated organoids of key inflammatory-related genes. H Amount of IL-8 detected in control and 50 nm MPs-treated colon organoids. The results are presented as the mean ± S.D. (n = 6). ^#p < 0.05, ^###p < 0.001 vs. control