Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 19;13:1023. doi: 10.1038/s41598-023-27706-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Bifidobacterium strains induce unique changes in local and systemic immune cell distribution and LN architecture. (A) Experimental design. C57BL/6 mice treated with antibiotics for 6 days followed by oral gavage with B. pseudolongum ATCC25526 (ATCC), UMB-MBP-01 (MD), or PBS (control). Mice then treated with the immunosuppressant tacrolimus for the next two days. Tissues harvested 2 days after oral gavage of bacteria. Frozen MLN sections stained for (B) CD11c + DC, and (C) F4/80 + MΦ. Small intestine stained for (D) Foxp3 + Treg, and (E) CD11c + DC. LN stained for laminin α4 and laminin α5 with their ratio depicted for (F) MLN CR, and (G) PLN CR. MFI values normalized using the sum of mean, and categories compared using one-way ANOVA. *p value < 0.05; **p value < 0.01, ***p value < 0.001, ****p value < 0.0001. Data representative of 2 separate experiments, 3 mice/group, i.e. 6 total mice per condition over 2 experiments. The raw files from these experiments are available at https://doi.org/10.6084/m9.figshare.21685850.