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. 2022 Nov 12;48(3):529–539. doi: 10.1038/s41386-022-01487-y

Fig. 3. Tropomyosin receptor kinaseB (TrkB) expression in the lateral septum (LS) is required for social novelty induced c-Fos expression.

Fig. 3

A Illustration depicting the anatomical boundaries across the rostral-caudal axis of the LS, denoting the dorsal (d), intermediate (i), and ventral (v) subregions of the LS. B Description of social or non-social cues used to induce c-Fos expression. C Induction of c-Fos is significantly increased by social cues in the middle portion of the LS (t6 = 5.543, p = 0.004), (D) an effect seen specifically in the intermediate (t6 = 3.697, p = 0.030) and ventral subdivisions (t6 = 3.131, p = 0.040) of the middle LS. E The viral strategy using cre-induced TrkB knockdown in the LS of TrkBfl/fl mice prior to examining social interaction induced c-Fos expression. F Knockdown of TrkB in the LS significantly decreases cell recruitment in the middle portion of the LS following social stimuli (t9 = 3.069, p = 0.0396), (G) an effect seen across the dorsal (t9 = 3.049, p = 0.029), intermediate (t9 = 3.254, p = 0.029), and ventral (t9 = 2.342, p = 0.044) subdivisions of the middle LS.